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系统生物学导论课程
关键字：系统生物学|计算系统生物学|系统生物学pdf

学校价格：￥电话咨询	网上优惠价：￥享团购	关注度：468人
总课时：预约咨询	开班日期：电话咨询	上课时段：全日制\|周末班\|寒暑假
授课学校：北京爱预科教育学校
上课地点：北京市海淀区清华东路

　　课程介绍

　　ThiscoursewillintroducethestudenttocontemporarySystemsBiologyfocusedonmammaliancells,theirconstituentsandtheirfunctions.Biologyismovingfrommoleculartomodular.Asourknowledgeofourgenomeandgeneexpressiondeepensandwedeveloplistsofmolecules(proteins,lipids,ions)involvedincellularprocesses,weneedtounderstandhowthesemoleculesinteractwitheachothertoformmodulesthatactasdiscretefunctionalsystems.Thesesystemsunderliecoresubcellularprocessessuchassignaltransduction,transcription,motilityandelectricalexcitability.Inturntheseprocessescometogethertoexhibitcellularbehaviorssuchassecretion,proliferationandactionpotentials.Whatarethepropertiesofsuchsubcellularandcellularsystems?Whatarethemechanismsbywhichemergentbehaviorsofsystemsarise?Whattypesofexperimentsinformsystems-levelthinking?Whydoweneedcomputationandsimulationstounderstandthesesystems?Thecoursewilldevelopmultiplelinesofreasoningtoanswerthequestionslistedabove.Twomajorreasoningthreadsare:thedesign,executionandinterpretationofmultivariableexperimentsthatproducelargedatasets;quantitativereasoning,modelsandsimulations.Exampleswillbediscussedtodemonstrate“how”cell-levelfunctionsariseand“why”mechanisticknowledgeallowsustopredictcellularbehaviorsleadingtodiseasestatesanddrugresponses.

　　课程目录

　　1SystemsLevelReasoning|MoleculestoPathways

　　1.1OverviewofSystemsLevelReasoning&MoleculestoPathways

　　1.2.1SystemsLevelReasoningI

　　1.2.2SystemsLevelReasoningII

　　1.3.1MoleculestoPathways-cAMPandGProteinPathwaysI

　　1.3.2MoleculestoPathways-cAMPandGProteinPathwaysII

　　2PathwaystoNetworksPhysicalForcesandElectricalActivityinCellBiology

　　2.1.1PathwaystoNetworksMAPkinasePathwaysNetworkI

　　2.1.2PathwaystoNetworksMAPkinasePathwaysNetworkII

　　2.2.1MechanicalForcesinCellBiology

　　2.3.1ElectricalActivityinCellBiology

　　3MathematicalRepresentationsofCellBiologicalSystemsSimulationsofCellBiologicalSystems

　　3.1.1MathematicalRepresentationsofCellBiologicalSystemsI

　　3.2.1MathematicalRepresentationsofCellBiologicalSystemsII

　　3.3.1SimulationsofCellBiologicalSystemsI

　　3.3.2SimulationsofCellBiologicalSystemsII

　　4ExperimentalTechnologiesNetworkBuildingandAnalysis

　　4.1ExperimentalTechnologies

　　4.2AnalyzingLargeDataSets

　　4.3NetworkBuildingAnalysisandDataOrganization

　　4.4BuildingNetworks

　　5AnalysisofNetworksTopologytoFunction

　　5.1.1AnalysisofNetworksI

　　5.1.2AnalysisofNetworksII

　　5.2.1FromTopologytoFunctionDirectedSignSpecifiedGraphsI

　　5.3.1FromTopologytoFunctionDirectedSignSpecifiedGraphsII

　　6StrengthsandLimitationsofDifferentTypesofModelsIdentifyingEmergentProperties

　　6.1StrengthsandLimitationsofDifferentTypesofModelsI

　　6.2StrengthsandLimitationsofDifferentTypesofModelsII

　　6.3IdentifyingEmergentPropertiesBistabilityI

　　6.4IdentifyingEmergentPropertiesBistabilityII

　　7EmergentPropertiesUltrasensitivityandRobustnessCaseStudies

　　7.1Ultrasensitivity

　　7.2RobustnessandScaffolds

　　7.3CaseStudiesI

　　7.4CaseStudiesII

　　8CaseStudiesSystemsBiomedicineSystemsPharmacologyandTherapeuticsPerspective

　　8.1CaseStudiesIII

　　8.2CaseStudiesIV

　　8.3SystemsBiomedicine

　　8.4SystemsPharmacologyandTherapeutics

　　8.5Perspective

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系统生物学导论课程
关键字：系统生物学|计算系统生物学|系统生物学pdf