系统生物学导论课程
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系统生物学导论课程

关键字:系统生物学|计算系统生物学|系统生物学pdf

学校价格:¥电话咨询 网上优惠价:¥享团购 关注度:477人
总课时:预约咨询 开班日期:电话咨询 上课时段:全日制|周末班|寒暑假  
授课学校:北京爱预科教育学校
上课地点:北京市海淀区清华东路
  课程介绍
 
  ThiscoursewillintroducethestudenttocontemporarySystemsBiologyfocusedonmammaliancells,theirconstituentsandtheirfunctions.Biologyismovingfrommoleculartomodular.Asourknowledgeofourgenomeandgeneexpressiondeepensandwedeveloplistsofmolecules(proteins,lipids,ions)involvedincellularprocesses,weneedtounderstandhowthesemoleculesinteractwitheachothertoformmodulesthatactasdiscretefunctionalsystems.Thesesystemsunderliecoresubcellularprocessessuchassignaltransduction,transcription,motilityandelectricalexcitability.Inturntheseprocessescometogethertoexhibitcellularbehaviorssuchassecretion,proliferationandactionpotentials.Whatarethepropertiesofsuchsubcellularandcellularsystems?Whatarethemechanismsbywhichemergentbehaviorsofsystemsarise?Whattypesofexperimentsinformsystems-levelthinking?Whydoweneedcomputationandsimulationstounderstandthesesystems?Thecoursewilldevelopmultiplelinesofreasoningtoanswerthequestionslistedabove.Twomajorreasoningthreadsare:thedesign,executionandinterpretationofmultivariableexperimentsthatproducelargedatasets;quantitativereasoning,modelsandsimulations.Exampleswillbediscussedtodemonstrate“how”cell-levelfunctionsariseand“why”mechanisticknowledgeallowsustopredictcellularbehaviorsleadingtodiseasestatesanddrugresponses.
 
  课程目录
 
  1SystemsLevelReasoning|MoleculestoPathways
 
  1.1OverviewofSystemsLevelReasoning&MoleculestoPathways
 
  1.2.1SystemsLevelReasoningI
 
  1.2.2SystemsLevelReasoningII
 
  1.3.1MoleculestoPathways-cAMPandGProteinPathwaysI
 
  1.3.2MoleculestoPathways-cAMPandGProteinPathwaysII
 
  2PathwaystoNetworksPhysicalForcesandElectricalActivityinCellBiology
 
  2.1.1PathwaystoNetworksMAPkinasePathwaysNetworkI
 
  2.1.2PathwaystoNetworksMAPkinasePathwaysNetworkII
 
  2.2.1MechanicalForcesinCellBiology
 
  2.3.1ElectricalActivityinCellBiology
 
  3MathematicalRepresentationsofCellBiologicalSystemsSimulationsofCellBiologicalSystems
 
  3.1.1MathematicalRepresentationsofCellBiologicalSystemsI
 
  3.2.1MathematicalRepresentationsofCellBiologicalSystemsII
 
  3.3.1SimulationsofCellBiologicalSystemsI
 
  3.3.2SimulationsofCellBiologicalSystemsII
 
  4ExperimentalTechnologiesNetworkBuildingandAnalysis
 
  4.1ExperimentalTechnologies
 
  4.2AnalyzingLargeDataSets
 
  4.3NetworkBuildingAnalysisandDataOrganization
 
  4.4BuildingNetworks
 
  5AnalysisofNetworksTopologytoFunction
 
  5.1.1AnalysisofNetworksI
 
  5.1.2AnalysisofNetworksII
 
  5.2.1FromTopologytoFunctionDirectedSignSpecifiedGraphsI
 
  5.3.1FromTopologytoFunctionDirectedSignSpecifiedGraphsII
 
  6StrengthsandLimitationsofDifferentTypesofModelsIdentifyingEmergentProperties
 
  6.1StrengthsandLimitationsofDifferentTypesofModelsI
 
  6.2StrengthsandLimitationsofDifferentTypesofModelsII
 
  6.3IdentifyingEmergentPropertiesBistabilityI
 
  6.4IdentifyingEmergentPropertiesBistabilityII
 
  7EmergentPropertiesUltrasensitivityandRobustnessCaseStudies
 
  7.1Ultrasensitivity
 
  7.2RobustnessandScaffolds
 
  7.3CaseStudiesI
 
  7.4CaseStudiesII
 
  8CaseStudiesSystemsBiomedicineSystemsPharmacologyandTherapeuticsPerspective
 
  8.1CaseStudiesIII
 
  8.2CaseStudiesIV
 
  8.3SystemsBiomedicine
 
  8.4SystemsPharmacologyandTherapeutics
 
  8.5Perspective
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