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- 课程详细介绍
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系统生物学导论课程
关键字:系统生物学|计算系统生物学|系统生物学pdf
学校价格:¥电话咨询 网上优惠价:¥享团购 关注度:475人 总课时:预约咨询 开班日期:电话咨询 上课时段:全日制|周末班|寒暑假 授课学校:北京爱预科教育学校 上课地点:北京市海淀区清华东路 课程介绍ThiscoursewillintroducethestudenttocontemporarySystemsBiologyfocusedonmammaliancells,theirconstituentsandtheirfunctions.Biologyismovingfrommoleculartomodular.Asourknowledgeofourgenomeandgeneexpressiondeepensandwedeveloplistsofmolecules(proteins,lipids,ions)involvedincellularprocesses,weneedtounderstandhowthesemoleculesinteractwitheachothertoformmodulesthatactasdiscretefunctionalsystems.Thesesystemsunderliecoresubcellularprocessessuchassignaltransduction,transcription,motilityandelectricalexcitability.Inturntheseprocessescometogethertoexhibitcellularbehaviorssuchassecretion,proliferationandactionpotentials.Whatarethepropertiesofsuchsubcellularandcellularsystems?Whatarethemechanismsbywhichemergentbehaviorsofsystemsarise?Whattypesofexperimentsinformsystems-levelthinking?Whydoweneedcomputationandsimulationstounderstandthesesystems?Thecoursewilldevelopmultiplelinesofreasoningtoanswerthequestionslistedabove.Twomajorreasoningthreadsare:thedesign,executionandinterpretationofmultivariableexperimentsthatproducelargedatasets;quantitativereasoning,modelsandsimulations.Exampleswillbediscussedtodemonstrate“how”cell-levelfunctionsariseand“why”mechanisticknowledgeallowsustopredictcellularbehaviorsleadingtodiseasestatesanddrugresponses.课程目录1SystemsLevelReasoning|MoleculestoPathways1.1OverviewofSystemsLevelReasoning&MoleculestoPathways1.2.1SystemsLevelReasoningI1.2.2SystemsLevelReasoningII1.3.1MoleculestoPathways-cAMPandGProteinPathwaysI1.3.2MoleculestoPathways-cAMPandGProteinPathwaysII2PathwaystoNetworksPhysicalForcesandElectricalActivityinCellBiology2.1.1PathwaystoNetworksMAPkinasePathwaysNetworkI2.1.2PathwaystoNetworksMAPkinasePathwaysNetworkII2.2.1MechanicalForcesinCellBiology2.3.1ElectricalActivityinCellBiology3MathematicalRepresentationsofCellBiologicalSystemsSimulationsofCellBiologicalSystems3.1.1MathematicalRepresentationsofCellBiologicalSystemsI3.2.1MathematicalRepresentationsofCellBiologicalSystemsII3.3.1SimulationsofCellBiologicalSystemsI3.3.2SimulationsofCellBiologicalSystemsII4ExperimentalTechnologiesNetworkBuildingandAnalysis4.1ExperimentalTechnologies4.2AnalyzingLargeDataSets4.3NetworkBuildingAnalysisandDataOrganization4.4BuildingNetworks5AnalysisofNetworksTopologytoFunction5.1.1AnalysisofNetworksI5.1.2AnalysisofNetworksII5.2.1FromTopologytoFunctionDirectedSignSpecifiedGraphsI5.3.1FromTopologytoFunctionDirectedSignSpecifiedGraphsII6StrengthsandLimitationsofDifferentTypesofModelsIdentifyingEmergentProperties6.1StrengthsandLimitationsofDifferentTypesofModelsI6.2StrengthsandLimitationsofDifferentTypesofModelsII6.3IdentifyingEmergentPropertiesBistabilityI6.4IdentifyingEmergentPropertiesBistabilityII7EmergentPropertiesUltrasensitivityandRobustnessCaseStudies7.1Ultrasensitivity7.2RobustnessandScaffolds7.3CaseStudiesI7.4CaseStudiesII8CaseStudiesSystemsBiomedicineSystemsPharmacologyandTherapeuticsPerspective8.1CaseStudiesIII8.2CaseStudiesIV8.3SystemsBiomedicine8.4SystemsPharmacologyandTherapeutics8.5Perspective编号 班级名称 开班日期 教学点 网上优惠价 网上支付
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